Why Mixed Mode Chromatography Resins Are Gaining Ground in Industry I’ve been around chromatography columns and resin beds for what feels like ages. What continuously strikes me is how mixed mode chromatography resins have turned heads in recent years — and rightly so. They deliver this nifty combination of different interaction mechanisms in one format, which frankly cuts down processing times and complexity in ways that old-school single mode just can’t touch. For those outside the chromatography bubble, mixed mode resins combine ionic, hydrophobic, and sometimes even hydrogen bonding intera…